![]() That said, some clinical trials and studies show a possible benefit, usually when combined with changes in diet and exercise.īelow are the highlights of some promising research: Research on Wellbutrin as a weight-loss drug shows promise, but because results are mixed and the weight loss is not significant, it is not an FDA-approved treatment for weight loss or obesity. Still, Wellbutrin is not a weight-loss drug and should not be prescribed solely for this purpose. Increasing levels of these neurotransmitters may cause changes in eating and, therefore, weight. It may have to do with the fact that the drug affects dopamine and norepinephrine, both of which play a role in appetite, satiety, and feeding behaviors. It’s unclear exactly why Wellbutrin has this effect. Wellbutrin, however, is most commonly associated with weight loss. Though everyone responds differently, most antidepressants tend to lead to weight gain. Weight change is a common side effect of any antidepressant. Tell your doctor if you notice new or worsening side effects while taking Wellbutrin. Side effects also tend to lessen as your body adjusts to the medication. Wellbutrin tends to have milder side effects than other antidepressants such as selective serotonin reuptake inhibitors ( SSRIs). It typically takes a few weeks to a few months for people to notice significant improvements from taking Wellbutrin for depression. Low levels of these neurotransmitters are associated with depressive symptoms, so Wellbutrin may help improve mood and other symptoms of depression. Wellbutrin works by increasing levels of dopamine and norepinephrine in the brain. Off-label, Wellbutrin may also be used to treat: Wellbutrin is most often prescribed for treating major depressive disorder (MDD) and seasonal affective disorder (SAD).ĭoctors also prescribe it to help decrease nicotine cravings in people who are trying to quit smoking.
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